Head of Functional Department on Rare Neurological Diseases
Head of Rare Neurodegenerative and Neurometabolic Diseases Unit
Department of Clinical Neurosciences
IRCCS Foundation, C. Besta Neurological Institute
Via Celoria 11, 20133 Milan, Italy
Phone +39-02 2394 3001/2445; Fax +39-02 2394 2293 email@example.com
Born in Turin, Italy, 21st June, 1959
Davide Pareyson is a Clinical Neurologist working at the Fondazione IRCCS Istituto Neurologico C.Besta (INCB) of Milan, Italy, where he is currently Head of the Rare Neurodegenerative and Neurometabolic Diseases Unit; he is also Chief of the Functional Department of Rare Neurological Diseases.
His main interest is clinical research on hereditary and acquired peripheral neuropathies and motor neuronopathies, inherited neurological disorders, rare diseases. He performed studies on phenotype-genotype correlation, clinical findings, electrophysiology, neuropathology of hereditary neuropathies (particularly Charcot-Marie-Tooth disease – CMT – and related neuropathies, but also amyloid neuropathy) and other neurogenetic disorders including spinal and bulbar muscle atrophy, hereditary spastic paraplegias, hereditary ataxias, genetic leukodystrophies.
He has been working on the development of outcome measures for hereditary neuropathies and other rare diseases and has coordinated and participated in clinical trials and natural history studies in inherited and acquired neuropathies. He coordinated the international trial on ascorbic acid in CMT1A in Italy and UK (Pareyson et al., Lancet Neurol 2011) and the observational trial in patients with ATTR amyloid neuropathy treated with Tafamidis (Cortese et al., J Neurol 2016). He participated in other interventional trials including the following: CMT (comparing two different rehabilitative approaches in CMT, coordinated by A Schenone, Genoa), CIDP (one coordinated by E Nobile Orazio with IVIG and pulse steroids, E Nobile-Orazio et al., Lancet Neurol 2015, and one international coordinated by RAC Hughes, published on Lancet Neurol 2012).
He is the Coordinator of the Italian National Registries of Charcot-Marie-Tooth disease and of SpinoBulbar Muscular Atrophy (www.registronmd.it), and participates as local PI in the TTR-related amyloidosis Italian National Registry.
He is among the organizers of three ENMC workshops on CMT and participated into three other workshops.
He organized the 6th International meeting of the Charcot-Marie-Tooth and Related neuropathies consortium (CMTR) in Mestre-Venice, 8-10th Sept. 2016.
He has co-authored 232 papers on peer-reviewed Journals (Pubmed) mainly on hereditary disorders and neuromuscular diseases. H-index = 41 (Scopus)
Positions and Honors
1981-1982 – Internship, Clinic of Medical Pathology, Milan University.
1982-1984 – Internship, IRCCS Foundation, C.Besta Neurological Institute (INCB), Milan.
1985-1989 – Postdoc. Fellowship, Besta Institute, Milan.
1989-1996 − Assistant Neurologist in the Department of Neurology, INCB, Milan, Italy.
1996-2003 − Associate Neurologist in the Department of Neurology, INCB, Milan.
2003-2007 − Associate Neurologist in the Department of Biochemistry and Genetics, INCB, Milan. 2007-2010 − Head of the Simple Unit (SOS) “Clinic of Central and Peripheral Degenerative Neuropathies” – Department of Clinical Neurosciences, INCB, Milan.
2010-2017 − Head of the Simple Department Unit (SOSD) “Clinic of Central and Peripheral Degenerative Neuropathies” (named Rare Neurological Diseases since 2016) – Department of Clinical Neurosciences, INCB, Milan.
2012- − Head of Functional Department on Rare Neurological Diseases, INCB, Milan.
2017- – Head of the Complex Unit (UOC) “Rare Neurodegenerative and Neurometabolic Diseases”, INCB, Milan.
Other Experience, Professional Memberships, Honors:
2016-2020 − Co-chair of the European Academy of Neurology (EAN) Scientific Panel on Neuropathies
2016-2019 − Chair of the CMTR, Charcot-Marie-Tooth neuropathy & Related diseases consortium
2018- − Chair of the Neuropathy Group of the EURO-NMD ERN (European Reference Network for Neuromuscular Disorders) (since November 2018).
2016-2018 − Deputy Chair of the Neuropathy Group of the EURO-NMD ERN
2013-2017 − Member of the Board of the International Peripheral Nerve Society (PNS)
2013-2018 − Member of the Assembly of the EAN
2016-2018 − Member of the Management Group of the EAN Scientific Panel on Neurogenetics
2013-2015 − Co-chair of the EAN Scientific Panel on Neurogenetics
2013-2014 − Member of the Election Oversight Committee for the EAN
2012-2014 − Member of the Executive Committee of the European Neurological Society (ENS)
2006-2013 − Coordinator of the Clinical Neurogenetics Subcommittee of the ENS
2017-2019 − Member of the Nervous System Commission of the Scientific Council of AFM- Telethon
2010-2013 − President of the Italian Peripheral Nerve Society (ASNP)
2013-2016 − Member of the Board of the of the ASNP
2008-2010 − Coordinator the Italian Group for the study of the Peripheral Nervous System (GSSNP)
Member of the Editorial Board of the following Journals: Neurology Genetics (2017-…), Neurological Sciences, Journal of Neuromuscular Diseases; previously J Peripheral Nervous System (until Dec 2016), J Neurology (2008-2012), The Scientific World Journal (2010-2013).
Member of the Italian Neurological Society, European Academy of Neurology (EAN), Peripheral Nerve Society.
Ad Hoc Reviewer for: Nature, Nat Rev Neurol; Brain; Ann Neurol; Neurology; Muscle & Nerve, Neuromuscular Disorders, J Neurol Neurosurg Psychiatry; J Neurol; Hum Mut., European J Neurol, Neurological Sciences, J Peripheral Nervous System, BMC Neurology, Clin Neurol, J Med Genet, J Medical Genetics, Clinical Genetics, Acta Neurologica Scandinavica, J Neurol Sci, Clinical Neurophysiology, Multiple Sclerosis, Clinical Neurology and Neurosurgery, Neurobiology of Disease, Mol Cytogenetics, Journal of Neuromuscular Disorders, Current Opinion in Neurology, etc.; grant reviewer: MDA, AFM, FWO, Wellcome Trust, ABN Clinical Research Training Fellowship, Agence Nationale de la Recherche (ANF).
Grants for research activities on CMT, SBMA, hATTR from:
AFM-Telethon # 20667 (Coordinator, 2017-2019) and # 20821 (Local PI, 2017-2019), from Telethon Italy-UILMD (Coordinator or local PI GUP04002, GUP05007, GUP10008, GUP09013, GUP10010, GUP13006, GUP15009, GUP15010) (for the 2005-2019 period); from AIFA (bandi per la ricerca indipendente sui farmaci) AIFA-2016-02364843 and 2005-FARM53APAH; MDA and CMTA through University of Iowa; Regione Lombardia (on rare diseases); Ministry of Health (RF-2011-02347127).